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About the Model:


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About the Model:


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About the Model:

This plot was created using the same method as used by Ibrahim, et al., 2016. Non-white observations were excluded from this analysis.

Covariates varied for each model. Proteinuria was adjusted for BMI, sex, and relationship to recipient. eGFR < 60 was adjusted for age, BMI, diastolic blood presssure, systolic blood pressure, eGFR at donation, relationship to recipient and if recipient has type II diabetes. eGFR < 45 was adjusted for age, BMI, systolic blood pressure, eGFR at donation, and relationship to recipient. eGFR < 30 was adjusted age, BMI, and systolic blood pressure.

Risk values are presented as cumulative risk in 5-year intervals. For each outcome, Cox regression with the full dataset after excluding non-white donors was used to organize observations into 20 equal-size groups based on the percentile of each donor's predicted survival. Subsequent Cox models were fit for each group and cumulative survival probabilities were recorded at 5-year intervals. For each new data point, predicted survival is estimated by the full-data Cox model and used to classify the new observation into one of the 20 groups. The cumulative survival for the selected group is then displayed on the graph above.

About the Data


The plot below displays the cumulative incidence of ESRD cases over time. This plot is unadjusted, meaning it does not depend on the inputs in the sidebar.

Of the 4297 living donors, 43 developed ESRD after a median time of 34 years. The average (sd) age at donation for these individuals was 35.6 (13.0) years and average eGFR was 91.7 (17.3); 63% were male, 88% white. Of the donors that developed ESRD: 37 donated to a first degree relative, 4 donated to other relative, and 2 were unrelated to the recipient.

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